Men tend to start business to make a lot of money. Women start businesses to create the companies that they want to work for—and typically don’t dream about building Fortune 500-sized giants that will make them billionaires.

Elizabeth Holmes is not your typical woman entrepreneur. And even though her habitual style of dress—black turtleneck and black suit—is Steve Jobs-ian, this self-made multi-billionaire is unlike anyone Silicon Valley has seen before.

Holmes founded Theranos, a blood diagnostics business, 11 years ago when she was a student at Stanford. She dropped out of college during her second year, relentlessly altered her vision and business plans, went on to raise more than $400 million in funding, and today runs a company that investors value at $9 billion. Holmes, now 30, owns more than half of this fast-growing health-care startup.

Last June, my colleague Roger Parloff did a fascinating Fortune cover profile of Holmes…